Genetic and Chromosomal Abnormalities
Geneotype: genetic makeup containing both expressed and unexpressed characteristics Phenotype: observable characteristics Mutations: permanent alteration in genes or chromosomes that may produce harmful characteristics (at least 1.6 harmful mutation per person in each generation) Many defects are hereditary and people pass them on Mutation leads to abnormalities in genes/chromosomes (can occur spontaneously or be induced by environmental hazards like radiation) Many disorders are a result of inherited disposition and environmental factors before and/or after birth - Ex: ADHD is a behavioral disorder transmitted multifactorially -> combination of genetic and environmental factors to produce certain complex traits Not all abnormalities are visible at birth: Sachs - not visible until 6 months Sickle cell anaemia -"- Cystic fibrosis - not seen until age 4 Glaucoma - not seen until middle age Huntington's disease -"- 1 in every 156 children in Western co...